A Diagnostic Dilemma: Normal Repetitive Nerve Stimulation in Lambert-Eaton Myasthenic Syndrome
نویسندگان
چکیده
It is important for the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) to confirm incremental response at high-rate stimulation or after brief exercise in repetitive nerve (RNS) test. Therefore, it may be difficult diagnose LEMS if RNS test normal initially. We report a patient with whose was delayed due findings. believe that anti-P/Q-type voltage-gated calcium channel antibody testing crucial LEMS.
منابع مشابه
Lambert-Eaton myasthenic syndrome.
Lambert-Eaton myasthenic syndrome (LEMS) is an idiopathic or paraneoplastic syndrome producing antibodies against presynaptic voltage-gated P/Q calcium channels. This decreases calcium entry into the presynaptic terminal, which prevents binding of vesicles to the presynaptic membrane and acetylcholine release. LEMS is most often associated with small cell lung cancer, although idiopathic presen...
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A new immunoprecipitation assay has been established for detecting antibodies to voltage-gated calcium channels (VGCCs) in Lambert-Eaton myasthenic syndrome (LEMS), using 125I-omega-conotoxin MVIIC, which binds to P-type VGCCs, to label extracts of human cerebellum. Fifty six of 66 serum samples (85%) from patients with clinically and electrophysiologically definite LEMS were positive for the p...
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The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltagegated calcium channels (VGCC) which is an essential component of the mechanism of neurotransmitter release. Many pa...
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Inspiratory muscle function was assessed in a patient with the Lambert-Eaton myasthenic syndrome that developed in association with a bronchogenic carcinoma. Repetitive maximal inspiratory pressure measurements and the electromyographic response to phrenic nerve stimulation established involvement of the inspiratory muscles in general and the diaphragm specifically in this condition.
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Two cases of Lambert Eaton syndrome unassociated with an underlying malignancy are described. Both had mild autonomic symptoms but markedly abnormal autonomic function tests. These results are suggestive of a widespread defect in cholinergic transmission in addition to that at the skeletal neuromuscular junction.
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ژورنال
عنوان ژورنال: Journal of the Korean neurological association
سال: 2022
ISSN: ['1225-7044', '2288-985X']
DOI: https://doi.org/10.17340/jkna.2022.2.15